Oxford Optronix have recently developed (patent pending) a novel device for detecting Acute Kidney Injury (AKI) in patients. Our technology is currently being evaluated in a number of important scientific studies and clinical trials across the globe.
What is Acute Kidney Injury?
Acute Kidney Injury (AKI) is a sudden and rapid decline in kidney function, leading to a build-up of waste products and fluids in the body. It is characterized by a sudden decrease in urine output, an increase in serum creatinine levels, and disruptions in electrolyte balance. AKI can be caused by various factors, including dehydration, decreased blood flow to the kidneys, infections, medications, or underlying health conditions like heart failure or liver disease and is diagnosed through blood tests, urine tests, and imaging studies.
Treatment involves addressing the underlying cause, managing complications, and supporting kidney function through medications, fluid management, and sometimes dialysis.
Early recognition and prompt intervention are crucial to preventing complications and to promoting kidney recovery. Serum creatinine and oliguria (which refers to a decreased urine output) are the most commonly used markers to assess kidney function, but they may not be the most sensitive or specific predictors of Acute Kidney Injury (AKI), especially in the early stages. For example, creatinine levels may not rise immediately after kidney injury, limiting its effectiveness as a marker for detecting AKI in its early stages, when intervention is most effective.
Oliguria is also often considered a symptom or a marker associated with acute kidney injury (AKI). However, it alone is not always a reliable predictor of AKI.
Urinary Oxygen (PuO2) Monitoring
Patients who are unwell or undergoing surgery routinely have a urinary drainage catheter fitted in order to continuously drain the bladder. Oxford Optronix have developed a unique within-catheter device (patent pending) that integrates a tiny, disposable, oxygen sensor connected to a bedside monitor. This device continuously monitors dissolved oxygen levels within the urine as it enters the catheter.
The partial pressure of oxygen in urine (PuO2) may be a predictor of Acute Kidney Injury (AKI) because it reflects the oxygen tension within the kidney tissue. In healthy kidneys, there is a delicate balance between oxygen supply and oxygen demand. When there's a disruption in this balance and a change in the kidney's oxygenation status, this change is reflected in urine oxygenation, which may thereby indicate potential kidney injury or dysfunction.
A few reasons why PuO2 might be a good predictor of AKI:
Scientists and clinicians continue to explore a range of biomarkers and indicators to improve the early detection and management of AKI, and PuO2 is among the emerging factors being studied for its potential in this field.