for the bio-sciences sector
A long-term goal at Oxford Optronix is the identification of specific clinical applications for our core competence in tissue oxygen and tissue vitality monitoring.
The WellBeing System is a clinical bladder tissue oxygen measuring device that samples the partial pressure of oxygen (ptO2) at the bladder wall. Patients who are unwell or undergoing major surgery routinely have a Foley type bladder catheter inserted via the urethra in order to allow urine to be continuously drained from the bladder. The WellBeing System uses a specially developed version of the Foley urine drainage catheter to additionally facilitate the positioning of a small, flexible, optical oxygen sensor to make gentle contact with the bladder wall. Once the oxygen sensor is positioned against the bladder wall, the WellBeing System provides continuous monitoring of ptO2 from bladder wall tissue in units of kPa or mmHg.
WellBeing's patented, technology provides a continuous assessment of local oxygen supply-demand balance, thus indicating tissue oxygen debt, a major determinant of Multiple Organ Failure (MOF).
Because global haemodynamic markers do not correlate well with microvascular function, WellBeing opens a new window of opportunity for patient resuscitation; based not simply on arterial pressure-based endpoints, but on crucially important organ tissue perfusion-based endpoints.
Oxford Optronix Ltd. has been actively developing the WellBeing System over the last decade. WellBeing’s optical oxygen sensing technology, electronic signal processing algorithms and sensor introducer/urinary drainage catheter are protected by a number of filed and granted world-wide patents.
WellBeing is now in a major, two-year clinical trial in the ITU at University College London Hospital (UCLH) funded jointly by the Department of Health and The Wellcome Trust. Entitled; ‘A single site observational study of tissue oxygen monitoring for detecting impending shock states in the critically ill and those undergoing high risk surgery utilizing the WellBeing system’, this ground-breaking clinical trial is being conducted under the auspices of Professor Meryn Singer1, Dr David Brealey2 and Dr Andrew Obeid3
1Mervyn Singer (Chief Investigator) MB, BSc, MD, FRCP(Lon), FRCP(Edin), FFICM is Professor of Intensive Care Medicine at University College London, an NIHR Senior Investigator, Editor-in-Chief of Intensive Care Medicine Experimental, and Treasurer of the International Sepsis Forum.
2David Brealey (Principal Investigator) PhD MRCP FRCA is Consultant in Anaesthesia and Critical Care at University College London Hospital.
3Andrew Obeid BSc, MSc, PhD is CEO of Oxford Optronix Ltd.